The question "How many people are in Twice?" is ambiguous and requires clarification. "Twice" could refer to:
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The South Korean pop group TWICE: This is the most likely interpretation. TWICE currently has nine members.
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A doubled quantity of people: If "Twice" refers to a doubling of a pre-existing group, the answer would depend entirely on the size of that initial group. For example, "twice the number of people in a room with 5 people" would be 10 people.
Therefore, without further context, a precise answer is impossible. To answer definitively, we need to know what "Twice" refers to.