Get Involved Fyrc

Leo Migdal

-Dec 8, 2025, 7:42 AM

If you're interested in joining the Finglas Youth Resource Centre, please see our expression of interest forms below. Once complete a member of the youth work team will be in touch. We are grateful to all our funders who help support the ongoing work of the FYRC. The funding received enables us to provide essential programs, resources, and opportunities that positively impact the Finglas community and the young people who live here. Thank you for your commitment to our mission and for making a difference in the lives of those we work with. Why not come along and volunteer with us!

Our aim is to recruit enthusiastic individuals who are looking for meaningful opportunities within our organisation. If you feel you possess a range of diverse interests, skills and experience and would like to give back, get in touch @ info@fyrc.ie If you are studying youth work and are looking to complete a student placement, FYRC is the place for you! We have a long-standing mentorship programme working closely with colleges to ensure your experience is one of tailored learning and development, helping you to achieve your career goals. For more information please contact info@fyrc.ie If you're interested in working within a dynamic and innovative service that strives to deliver high quality youth work in a fantastic community please contact info@fyrc.ie

*Correspondence to: Mark Bycroft, MRC Centre for Protein Engineering, Hills Road, Cambridge, CB2 0QH, United Kingdom. E-mail: mxb@mrc-lmb.cam.ac.uk Received 2010 Mar 24; Accepted 2010 Apr 1; Issue date 2010 Jul. Many chromatin-associated proteins contain two sequence motifs rich in phenylalanine/tyrosine residues of unknown function. These so-called FYRN and FYRC motifs are also found in transforming growth factor beta regulator 1 (TBRG1)/nuclear interactor of ARF and MDM2 (NIAM), a growth inhibitory protein that also plays a role in maintaining... We have solved the structure of a fragment of TBRG1, which encompasses both of these motifs.

The FYRN and FYRC regions each form part of a single folded module (the FYR domain), which adopts a novel α + β fold. Proteins such as the histone H3K4 methyltransferases trithorax and mixed lineage leukemia (MLL), in which the FYRN and FYRC regions are separated by hundreds of amino acids, are expected to contain FYR domains with... Keywords: p14ARF, chromatin, taspase1, proteolysis In recent years, it has become clear that chromatin structure plays a central role in regulating processes, such as transcription, DNA repair, and DNA replication. Consequently, proteins that modify or remodel chromatin are currently subject to intense interest. Many of these proteins are modular and contain domains that reoccur in numerous nuclear proteins.1 The FYRN and FYRC sequence motifs are two poorly characterized phenylalanine/tyrosine-rich regions of around 50 and 100 amino acids,...

1(A)].1–3 They are particularly common in histone H3K4 methyltransferases most notably in a family of proteins that includes human mixed linage leukemia (MLL) and the Drosophila melanogaster protein trithorax. Both of these enzymes play a key role in the epigentic regulation of gene expression during development,9 and the gene coding for MLL is frequently rearranged in infant and secondary therapy-related acute leukemias.10 They... To be fully active, MLL must be proteolytically processed by taspase1, which cleaves the protein between the FYRN and FYRC regions.13,14 The N-terminal and C-terminal fragments remain associated after proteolysis apparently as a result... How proteolytic processing regulates the activity of MLL is not known. Intriguingly, the FYRN and FYRC motifs of a second family of histone H3K4 methyltransferases, represented by MLL2 and MLL4 in humans and TRR in Drosophila melanogaster, are closely juxtaposed. Explore the primary meaning of FYRC abbreviation as Finglas Youth Resource Centre.

The Finglas Youth Resource Centre CLG has been providing youth work programmes, informal education and opportunities for young people since 2004 providing counselling services for youth in Finglas. The youth centre itself is purpose built and has been providing a place of welcoming and belonging, a place for the young people to come and be themselves, providing a safe space to learn,... Supporting the personal and social development of young people from the Finglas community where young people are safe, recognised, empowered, and supported to reach their full potential. Through partnership and engagement, we support young people in building confidence, developing new skills, and reaching their full potential in a safe and inclusive environment. The FYRC meets the needs of young people by providing them with a variety of response-based supports, fun activities, and opportunities to enable them to learn, grow and be safe in their own community. Finglas West - 272 | Finglas South: 148 | Finglas East: 42 | FInglas north and other: 120

The FYRN and FYRC sequence motifs are two poorly characterized phenylalanine/ tyrosine-rich regions of around 50 and 100 amino acids, respectively, that are found in a variety of chromatin-associated proteins [1,2,3,4]. They are particularly common in histone H3K4 methyltransferases most notably in a family of proteins that includes human mixed lineage leukemia (MLL) and the Drosophila melanogaster protein trithorax. Both of these enzymes play a key role in the epigenetic regulation of gene expression during development, and the gene coding for MLL is frequently rearranged in infant and secondary therapy-related acute leukemias. They are also found in transforming growth factor β regulator 1 (TBRG1), a growth inhibitory protein induced in cells undergoing arrest in response to DNA damage and transforming growth factor (TGF)-β1. As TBRG1 has been shown to bind to both the tumor suppressor p14ARF and MDM2, a key regulator of p53, it is also known as nuclear interactor of ARF and MDM2 (NIAM). In most proteins, the FYRN and FYRC regions are closely juxtaposed, however, in MLL and its homologues they are far distant.

To be fully active, MLL must be proteolytically processed by taspase1, which cleaves the protein between the FYRN and FYRC regions [5]. The N-terminal and C-terminal fragments remain associated after proteolysis apparently as a result of an interaction between the FYRN and FYRC regions. How proteolytic processing regulates the activity of MLL is not known. Intriguingly, the FYRN and FYRC motifs of a second family of histone H3K4 methyltransferases, represented by MLL2 and MLL4 in humans and TRR in Drosophila melanogaster, are closely juxtaposed. FYRN and FYRC motifs are found in association with modules that create or recognize histone modifications in proteins from a wide range of eukaryotes, and it is likely that in these proteins they have... The FYRN and FYRC regions are not separate independently folded domains, but are components of a distinct protein module, The FYRN and FYRC motifs both form part of a single folded module (the FYR...

The FYRN region corresponds to β-strands 1-4 and their connecting loops, whereas the FYRC motif maps to β-strand 5, β-strand 6 and helices α1 to α4. Most of the conserved tyrosine and phenylalanine residues, after which these motifs are named are involved in interactions that stabilize the fold. Proteins such as MLL, in which the FYRN and FYRC regions are separated by hundreds of amino acids, are expected to contain FYR domains with a large insertion between two of the strands of... The profiles we developed cover the entire FYRN and FYRC motifs. ------------------------------------------------------------------------------- PROSITE methods (with tools and information) covered by this documentation:

Contributed by Speak Up for Kids Student Intern Team — This article was developed through the combined efforts of multiple student interns, each bringing unique skills and perspectives to support life skills education for... Approaching 18 is like looking over the edge of the world's tallest roller coaster. Now add in turning 18 while in the foster care system and you might feel like you forgot to put on your seatbelt! That's where having personalized support makes a huge difference in reaching your goals and planning your future. At Speak Up For Kids PBC, we know that everyone’s journey is unique. That’s why personalized advocacy through our Foster Youth Resource Concierge (FYRC) is key.

To refer yourself or someone you know to our concierge program, please fill out the referral form here. Forget about one-size-fits-all! Personalized advocacy means getting support that’s tailored just for you. The FYRC takes the time to really know you, understand your challenges, and find your strengths. With a unique plan we can help you tackle obstacles and move forward with confidence. One of the coolest things about personalized advocacy?

The trust you build with your advocate. We're not just here to provide a service. We're your advocate, guide, and cheerleader all rolled into one. Our job is to listen and support you every step of the way. As we work toward building that trust, it makes opening up about your concerns and dreams a whole lot easier. Because hey, you've got a dedicated ally in your corner!

Empowerment is everything to Speak Up For Kids! The FYRC program is about giving you the information and resources you need to make smart decisions about your future. From choosing the right educational path to managing your finances, we’re here to help you take full control of your life. We’ll equip you with the in-depth knowledge and skills to navigate life’s challenges and take advantage of opportunities.

Get Involved Fyrc

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If You're Interested In Joining The Finglas Youth Resource Centre,

Our Aim Is To Recruit Enthusiastic Individuals Who Are Looking

*Correspondence To: Mark Bycroft, MRC Centre For Protein Engineering, Hills

The FYRN And FYRC Regions Each Form Part Of A

1(A)].1–3 They Are Particularly Common In Histone H3K4 Methyltransferases Most