International Clinical Council On Fibrodysplasia Ossificans Progressiv
The ICC is an autonomous and independent group of 21 internationally recognized clinical experts (MDs & Dentists) in FOP from 14 nations and 5 continents. In June 2017, the International Clinical Council (ICC) on FOP was established to consolidate a global voice for the best practices for clinical care and clinical research for people who suffer from FOP. on best practices for the care of individuals with FOP. on the design and conduct of interventional trials in FOP patients(Dec. 2, 2020 – Editorial from the ICC regarding clinical trials) from time-to-time the FOP Clinical Guidelines.
Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic condition characterized by congenital malformations of the great toes and progressive heterotopic ossification (HO) in specific anatomic patterns. Present management summarized here is focused on early diagnosis, assiduous avoidance of injury and iatrogenic harm, symptomatic amelioration of painful flare-ups, and optimization of residual function. Twenty-one members of the International Clinical Council on FOP (ICC) and seven consultants from 15 countries, chosen for their clinical expertise in FOP, developed this summary statement. Further advances in therapeutics will be based on rigorous clinical trials to assess novel and emerging treatment and prevention strategies. A detailed and updated exploration of the topics outlined in this brief perspective can be found in "The Medical Management of Fibrodysplasia Ossificans Progressiva: Current Treatment Considerations" which can be found on the International... Keywords: ACVR1; BMP signaling pathway; fibrodysplasia ossificans progressiva; guidelines; heterotopic ossification.
© The Author(s) 2025. Published by Oxford University Press on behalf of the American Society for Bone and Mineral Research. F.S.K. is a clinical trial investigator for Ashibio, Incyte, Ipsen, and Regeneron and serves in an unpaid capacity on the Medical Registry Advisory Board of the International Fibrodysplasia Ossificans Progressiva Association, the International Clinical Council... M.A.M. is a clinical trial investigator for Ashibio, Incyte, Ipsen, and Regeneron, and serves in an unpaid capacity on the Medical Registry Advisory Board of the International Fibrodysplasia Ossificans Progressiva Association, the International Clinical Council...
G.B. has research grants and conference support from FOP France and Ipsen, is a clinical trial investigator for Incyte, Ipsen, and Regeneron, is a member of the Medical Registry Advisory Board of the IFOPA, of... A.H.B. is a clinical trial investigator for Incyte, Ipsen, and Regeneron. M.B. is a clinical trial investigator for Incyte, Ipsen, and Regeneron.
A.C. is a trustee of The Radiant Hope Foundation. T-J.C. is a clinical trial investigator for Incyte and Ipsen. C.C.: None declared. C.L.D.C.
is a clinical trial investigator for Incyte and Ipsen and a member of the Medical Registry Advisory Board of the IFOPA. P.D. is a consultant for Ipsen, a clinical trial investigator for Incyte, Ipsen, and Regeneron, and a member of the Board of Directors of Tin Soldiers Global and the Noi Ci Siamo Association in Switzerland. R.J.D.: None declared. E.M.W.E. is a clinical trial investigator for STOPFOP, Regeneron, Ipsen, and Incyte, a member of the Medical Registry Advisory Board of the IFOPA, the steering committee of the Amsterdam Bone Center, the European Reference Network...
L.F.: None declared. C.F. is a consultant for Ipsen, Clinical Director for The Special Olympics, a member of the Board of Directors of Tin Soldiers Global, and has received an honorarium from Springer for a presentation. Z.G. is a consultant for the Axdev Group. N.H.
was a clinical investigator for Ipsen. E.C.H. serves in an unpaid capacity on the Medical Registry Advisory Board of the International Fibrodysplasia Ossificans Progressiva Association; the Fibrous Dysplasia Foundation Medical and Scientific Advisory Boards; and the International Clinical Council on FOP. ECH receives support for clinical trials through his institution from Clementia Pharmaceuticals, an Ipsen Company; Ipsen Pharmaceuticals; Ascendis; and āshibio. R.K. is a consultant for Ipsen, Alexion, Kyowa Kirin, UCB, Amgen, and Richter, a member of the Advisory Board of Alexion, Kyowa Kirin, Theramex, a clinical investigator for Alexion, Kyowa Kirin, Incyte, Ipsen, and Regeneron,...
J.K.: None declared. C.E.L.: None declared. V.M.: None declared. R.M. is a consultant for Ipsen. J.C.N.: None declared.
C.S. is a consultant for Ipsen and was a previous clinical trial investigator for Ipsen and Regeneron. E.M.S.: None declared. M.A.Z. was a member of the Clementia/Ipsen Data Safety Monitoring Board (DSMB) during the Palovarotene clinical trials and is currently on the Incyte DSMB. K.Z.
is a clinical trial investigator for Incyte, Ipsen, and Regeneron. R.J.P. is a clinical trial investigator for Ashibio, Incyte, Ipsen, and Regeneron, a member of the Medical Registry Advisory Board of the IFOPA, and a consultant for Incyte, Ipsen, and Regeneron. RJP is a co-inventor for the use of Andecaliximab in conditions of heterotopic ossification. Targets and potential therapies for fibrodysplasia ossificans progressiva. ��),&-6l~F�~X���^�;+������e)��R���|K9����1��\��� �,���ρE�FQ�qS��R�1R��P|�l������O�����^,�Rz��V��ҡ�=�� =��0h X�ߧ���l�mOa��f*樏(��3�Y��&� �KOfa^����>�}Leg���ɝ������S٧T^����jr�k�*�3U��e���m�o�[���Ür��$�4�9�^+�ֲ�_Q���sRi����W�h��Y�[3&N�_3�?}Lx��9�t�]cӧ� c� [@_����-~���x�}?��3�"{ �G$W���-�wG$Cx���:�G�+U�V�?�O���j�f�:�sH��4|FȨ0���«FҘ����F]����6��_��J�+X�w��{���w���)��=�{ʮ��O('t�w�'�ON�@^���YJ�k r[A�DV��4�2���z}����S .��_ \� �M�G�C���4r��nx�@N�6*���Ƙn�2��c���Xa�2Vk� 9'rN�16[���K�V��#�C�c���8`2��s�s����p�x�e��̭6Ng��9^�RN�q5�O�\]�q��g���Y�H���G���n�q{Y�1�}&��o�V9F�����7��'�+��T��ԙ._�RWi^���|�.�pؾ}��rF~&ߓ�~s����>��[wg���|w�ۗ]��+���{�{���]�^�^�^�^�^ ��7��\7V�xՈ7 ���㵍�UG=�eDbt�w!~'B������w������;H-m��F�}Б���V�N��K��-w"��k�\�� ��1!�K��t�TV�����JN��|�9�%�}^o���W����}���و91���}��k�j�j,9�k��"�:�,�m�m�>��v������������I.�a�+%ksþ��ެF�1� �)_��s9CY�|g���\n��BN���Z�t�M��w'��w��_�g�t���|����+���d����_��/��/�/�����u�W�[\�nMV��Ͽ>�ҿi$]�[�����*���w��g��}��r.�������VNڒӗ���-���!]o��?�MW6Ƿ�� 9�EK���J{ �מ�� <%ks� � D]9]��n���Ӿ�I��Mf���>��x߄v� ,N��{a`�x����,+���,�R)Y`u ��_��a�����8+x�~Þ~K�6�J`��N`��<�ٷ�5؊R_/��]�x)�;�7��~�@�P����<=���|3G��}N�3ka��x+�:'a� �.i�w��+-9���[��7��m��e�*p�p.�����7 �!�k�o�r�ʈO����_m�� 3�m�lc���Ւ�c��n�.�Z-��.pZ���g��y� ��ܵym��}�FsvCn��j���26�Ӿ�F�����@������Q�]2-�TƏ���ה3�l��Փ|�,�o�M��nj�x���Ȟ��o0��[*s8�>+g�i��������B}f�w���贷�8��\\�mu�fE���V�:ok�U�Fg�w�s��ݻó���wg�O��ȻǓt��:��~�|��ɳi�y겢�s�ӄ{a�Y��RYk��=mS ����܅>@�H/����e�d�R.)�Hy��<����N�x�ʔ�6e/�4�rh�m�a�˻�����u���[��^�{�#�Y:��efƕ�+*�o[����o�|0��TZ���� eJ&�kB�Ņ&P*���6�̏��q����y��K͐o�d^R��^�?m�{�2�۳�s���s�r�X�Q�}z��㞭�>ӟv='Ǹ�������\���{�s�scĵ�=� �G����� ����[9��r&��BA�eO�oO�G���u����d�(y'%�ϑ�?!�����a?O�k����Z������ �v��C�y��A�+J��c��AJ����y楿��� �D:�4@ʳ���H9�vf���r�qK�nj�F...
�bMe�{.�,��� ��p����7�֎T^P�N����� �,R�[Vj���'1�@���߈� b�E��c�� 1ڈ1 bTȥu�[����������u��b���^_�>���W>��2ՈDm�H��S��\�VxI��^�\��؆Y��0� i�F��˛�.O�Kb�"_Ex���ʜ!��p����2�����8����\��u��[�l�؋��f~rS��{�� ����cm����r:� ������A(�&5աFԂڋ�ڞz��4V��7�{�;5�T��M�����f�F�;xR��}3�+H���� a���7 ���n�] ������C��;+����+R�/ͤ����[!B���[<���T�*R5�_G�e�W�Ĕ��#Bc=������^�_��>�t���T�j�3o�IA���{�.9� ��f���"}ޤ��{��<�����&U����Ll�d��p��������B����z�����#x�S�����&��W�RCSl���n�zO�O��|2��8�c���������%�&u��I��C�$�&�ŵ5H��&U>�� 2L��~��EkC�B�aD�q6 �Q)B���"�2jE�]�p9e�VCը�,���"�_>�"ԭ�!9/VU�)���J+b�-徒���v��v�� �c�>�s@i,cQ">柲FY��tV�ܒ��c�銜�$g���i�2H�O��{�1�i Q:ȧ�I>�p&��P�*�H~UR�|�d�E�VC�R�yM�Kan��"�4��"�8NJ�a)�������V�w�d;eo���Fo~H���g�6q�Ң�Q�C`;��=��;�`G�v���-1�/���}���}��}OQ�(��ȭ���zj=�K��ؾBl�[E���7$��Q��H'�wBݘ|�ZG[H\��j�8]B�I�"�FE���c�VY^����y}���-��X���dm��}�~��?�ǟbOY�ęD����^�_��Q4��=u� QGo��}t�N�9�b�E��)��ץ����(�^ɫRbJ�(?�D)��4QZ)�.J��� S┉�4%Q��,QG��+�b�pLjsQձ� zx����W'w�HU�(WU'ɜR' �U���#��t��� ���������>���������!����Cm��G��c�=&K�~\(k��q���)��pO�B7�3�Yផ�����{^� � �h3��K½�_�e��~E�*\��U�&r_�.�]x��ߔߟ�o�ol�=W�~G�zU�+J�*�~U�V�^5��R���/z(�����(���T��6<��S���,, }�ۙF5��狼�EY]A��LhI:� e�fJ/��˔}�5博Qu��Vj_�K�ԃ�-!HYX�¾}��l;��\�=�����Jtmr�p=�:��0ux>����3��fjAZ��@��ⴅ����'�O~�2>M|~���g����u?��^^o���'�+�"�ߥʔ*4U�TmR�O5-՚T�R��U}�}#|�����;�w��1���f�D;��1̘cl1N�M_3�YҬgv5G���m�93ɲ��V)����k-�vY��Wv:;�.k7}t�F"�l�%����]�w�$$$�Aƀ�� cAƂ�u�q �@�9�x�� �d�� 2d"�D�2 d��L� 2�A��L�� � �... C%���Mg<>W��_<^ �ۆuՄdD2�3�G{>`܂Q �NQ� (:��[�sڅ9s�0ޅ9�����1> �Qo^���R�EB��s��������Uf����O���s Czc͝`�����8��q��C�!�[{�>7�� X������?�@�}��Z�+����#c�IJY�9��R��ӣp�ɭ�H9������s��5f������*X�y��"�\������1=1̚������w� �}�&���ٯ� k�"RU'(�G�"��+\QE��s���R0���� 7nѱf/xox#�H22~6n�L>�v��S�V�%�`d_n�kR^ ��=]_�Ya+�Bdd���,3� ���&���{�sk T�2�Xv{��� � f�6*�8���U��K��">�U��ށA�u�6M:�"� B���e��r����x�Y� �(��SӚ2m��qmBn3�F���-���.��{��5i�p��:}}?}e�0w��K��/h�G�~bC�y�0��+�!}2D�4ٮd2�sdE �A��+� 5t#(?������6�ӄK>�G��]k�3̘x�??w( �g�y�Z�;�U��f�k��9�#����ˣ��nW��s��MZ���ȑ�hQ��s�Ƈ�=7[���C���u�iwf��g������km ��4�ڃ7�E�����0( ������n����U|~sb&��s�.�X,(6`w/ ��BZ(m�{ʼn)/��m�wi:c�V��.aEY�$�h�h+�B���x��$��t^`� ���#KEK��ȶ�y��{�D�b3- q5���cF��Bm�fJ>�����S��W�bݐIq!z�t� �G�nZ�xb���n)vW�2/Ⓤ��^�kǭ�9�Bٷ:�u]�G^Ύ�q&�h�1�&�$0ַ��8&F��;�� ��qIsY�1��=ݬ�TsL�� ��j��i.�6:t�.�\#�{-���J써�LчH��TQF������RnD�n��}���k�l��w�!�����Ѧ��W9�K��B��ͺ�ɾ��T�/�H������*�C��ė�E��M�[�y�_+Ŀ}ζ�'��.��� N��C�b�n#�P(%@II �d�'�4��>u[�y�|�G��1w�����+ʔ�pΨ'��"0��j�Щ>�D|���|9���M�ҷ�ݍ�w�˨Oy���~^I���J3P%K���àgZ���Sqso�n��&)�����������U��]�c3�qj*:��\:�d;�����a��2����k�ù��dUm���L�#N�:~��?"��Q�5=ţ�ob��O���g����r���[q8Ԅ����L��t��VѬ�� ����Y endstream endobj 279... � 0�d��0��Q+&��Ӽ�b�� P:�0�������*,(b�*��B�bx{��y�*����C���(��h >R��gV��k����h����;NVϙ�f[���o&�Zώ��kV�v!��S��S/�.Ŭ��|��OT�f�X��� ���R�hƢR�ۻ� ��1~,@͡h�R�nl��EJ�\?�KS���P�w@�5�8-<�B�W-**L�RkN\d-r��Ԋ���u�ɇN�hJ��Ӟ�._�|b7X�G:�� ��7G|���#{#�L���gۖ)ؕ��ڠp�)z�B�jbb�~�!�t�m��-����Ax� �`2�� SdF�q0r��۸����h�ٛ���_�S>T>���v����� N��~�lq����vN���5�.X�-���8h�if�jVƐu��H]�nU��m�<܆y`�z�'c�<�B�#�?��G�r`����lY�j[v�5�b�<�_\U`i��n�F]���B]f������~�r��,[M;l�Z�Mv3��3e�N�_���d���lXh2�����f��2o`��9� v 92���;w,\Ӵo��[z콟|�qp̺�b���.��ש��=��Ά1e.��+�ۦ$.�������iN�٨'���� ZpO��z46� �����(Oe�_k��ʠ��~���Z��¨��V�wU��ǫ�zWg����5<4�6!TMgɳt l�BKu���u��>pY����) M �`��J9�ck��c>|�Ţq�13Lb�Ps�U��낟�.�ɫU9~T�T0U0� Y̭n�6j`c �t����<�� �R�T��^�^��j���ͪ���bM�]�gw�tk�v.�R��+��S��;LX'����{(ʉg��`����h0���2�|�\�)��'r���`�0�&,G��U�$3�hc�W8Y��+�� ��ύ�^�UW �x zdnS����<�����>�(s��K�{��/ �� ������fNO�������h��}s�[�?�z�2��c���4��K|d/ߝ07a��NЃSa��/��^1�RJش��Q-%^��V�_h �r�e�-«`m�eN+0ێ���_l�Q���}l9I������M���E���Ř�X2 V�-��4�*کr��Sa�Nޢ�����^��������~�AΈ�aDJ1���=,7���AᲖ�*Y��M'��N>�+��t}�4�Ĵ��� 绮s]9�|�W���+�J�BX��1.Q�����E��a�n�q���t���v���@O���.¼J�]�:�����7�X?�F�h�h�h+��h!��,��X����BOF�=��d6A<���8���-C�-C�-��ҭ֙Y�����8��{;�k���';�Mg�l+��LDt������ F�!*`Y���g��p�Y��zI ��uY#H�7 >�d��͂�$�p� u1 ��|7�s�3TFPcwt�]M^�x�7�~S}����>�(q�[6T�[�i��{]�m��=�֬z���[���3��<����=G����&�0o��i37���,�6慺5/�A��>�YԓL���p��g�~�Ò9y�&�>�+V����忹a�_+��j�����L�=���W��Wߠŏ8��p��C� B���NsB�V�d=�b�aI0��݈�=�ݺ��C... ���a��C���\1CՁ:lvj�[���HsJ���r�n����=��L�R��y6��(')T�u�C�l���H��v��a|8�W 96�q��&��qP��H|t7���h��%!�9'�P�v3�H\�b�8liv���RfKzҜ�� 0A"�X�e�V�<��=�c���9�.��g����k�=��G�=�^��}�ړ�������W�K<��5��\T<7;����=u��?ޠ�z� �f��������+���CWjBV�\��ă�\��]�s� ���2pn���Y��,�#f�ȯ@�����]Z��K؈������Lp^p@�37������.��H~G��g�7<��8\x� �ڝtM�Ot'%p4$;F|mnwڴp�z��-�(�n�r�ox�@�Ί��{ GF�����@��ke&S�����:�PЃ[�9�7La���7��e���ÒG 'K�����B2���� � t��?�z�*I���)�����SreG*iO�q"h���J�S*��g?�=���,��$J�q��O�A`)$|��AȊ�G}��(A\*��P I��\��� z��B�6����F!��I�,lb;� �>�˲}p]�ܹ�%v��2�) ��ѐ= ĩ��%�v��7�A� ����$�p|��r����=f�B2 ��8�-Q_��$���R��r�O�-v0�����|od���z`?���+ݫ����#yC��Wb������]�B{�$�a���������;\~Ӈ�p���(c<��]mH��y�U���pyR/�O�L+�/��:%�m��먌��̄r���Ƅ�Q�y�����S�<��y!��zB8�f��c�� ��[�Ve2;Y��?�=[Y俀�@Y�\�ί�~�7��C���v�,H��}q�aY���$?�����&��j!�W���T(�ϊ��gk�_��'�!T���?���C�"�q��Hӣ�z��� �c����@`�>K� ]E��3�L�㡄H01&�`�D+6��E�`NoW���}�����P��g DB��@�)K'�W�� 8v� bn�����bK<��:�p��bs���L(L ���"P�^�/��Ip���� =��Zx� ����,Ӊ��� Ж���a:�e�kˊ�D'o ��r�������td���yvU���*^���\ ��EX��ӻ�����?�ۭ;�ߜ���'��v�Aѧ!����!SFY�Bw�yO�z]��tQ*~g��踯�Cބ7�^��bX�yd`�A@�uf�wK�Ɖ����hs�W2�8'm��$�U�\���V� u��a_��a���k�z-c�a� �e��� g3a��P;ۼ,e� +�e�R� �Z�... E;�v4X�Z M7���I����4z��F�)'r��D!�� ks�dS�A0�h�À��%i�~*a�O�M���7�\��(��'�����s��M&�jYu����|v��ۗ$u�w��(p�N���[�Z �n}��x���~�!P_��|��ۓ�w�r����C�߾*��,�ڏ0�hJ���][d{ed��s`sҁ'ơQ8U:�#�UF��G�M���u��ҥ�@W*GM�I8p'ëFn������I3Wo���WG�uC/�F���ګ��.E�������ѫO�J#=����t�+�����7T��:���V2M� �� �s�u2>g��%eB�˕*o@I!>.�yFND�4��.����z���su��]K�N4��J�e={j� oZ�!�������1����2�T3sN������ս� X�S��Ţ1�CQ<� �ˠ���II���8m�V2�T����B����d��'��SmU+C�S-.<'s��~�0�P4v��}c���;X�7U�G��Q�s�m�z�v�5�S�� �X�S6"#2N�H嬃ڕ��^�[�ǵ�� �MQ� ����������g��3����n%��!D�jzB�'��[)|&��嗰���D�S��R�W2������!��2�L��,�+g0X#�d�F̀QJ�����Db�2��5J�D��J�# j� C�X^�Z�F�epH�c���rչ\ Z�_I�_y�| LBG�$����\2���_}m�،��0a�R���04����yP��4�TgCcL`��= �@��3�+J2���a�& �I���D�5ЉΔ�� 8��� ���������3� >ƥu9]��U�9%��dJ���P�v�͊��1mL4�Ѹ6�|4.�ѩ8:���;����2�����#�ǗW8_T0=>��Qn��ب�����������5c@�o��M��k����?��}���f�{��Z�������c 7� ԧ�����}��M���V�e�+�����;p���u'>���?~��������NLL6�>^ TH,�:�;j��Rc!T7�;ԤI�!%6�� Fcr=����f���$v��ZI��+(/��&�(�^\�j(�Hz�h�-��TH��:��c\�ю���Μ��p�K��(?k��y��� U�]����Ρ� {s`��#��_m̿�ؚU?�.���xs�}mQ�Շ�(K�@ȸ�F�x�t��),Le�����[��� ڲ�t�����(�!z���o���ZhOM�d#���e���^z�ȉ�n�G8�S���T&F�̀@Wa��O1r 2s�y{��K�]C�i@�g����<�G.�Ā�i'��X!�؍f��.�P~Ci}�� ��d��N�ݙ��$S�K��W��F6�h����Ὑ�u����K�FUyK�箫����h���]-��\���Y�|v�fҗx���%�-C �:� ��t [��m(����N��`��{�U[�Cb"mw�w�eH�zF�;��gZ�1M�C�,9�a����H�0Sݔh^i'ۍ$hZQQ�_�-c1�_�ѳ��`K�!t_��Sg���� }��>�h�ӷ��-�;��l�����... ��ꠎ�r=�ڭM�L� N�����:l�V�P)�b|��+����aҟ3�C�ya��Nhs�'�̈́�t�f�v-4h��T��zf}.,υ\Ư���Y���,�c�K=L���� �FŪ���L�6�dd�f�Y{��Yv�$ M�=9)?9cj�$�� ��GP�7�F�7�Ơ%I��Sԕ�� �Q���o�ھj��>��i���`%w�+n�2+�Q�-8��~tEpƭ�i}t[�f�Yo�.��"���?����e��C�ʊ�rGz��l���l�iƂ5e���6ݱ8u�4���e�e��b�� 4�|;�@�� �9?p�����}�j�}�4��ji>��4Nj��w�����&r@�%��D�'�=l� ӛ��K��H-u��D�s��)r��%{c�����\�]��YWle_�+f��/�v��ύ,��� ���[�K�g�� �w�%#Xj)���Xj ��ҥ��(Tb�%b�y�R²D�a@h:���B�p``@+ ǰB;!IQe�0X&��Fr�e��Aw��b����j���|��P(Uʥ""5j�����0:�_��\.����N�w0�����_ Z�J�U��*�Q�<��J9��%���T��!`�t3(�p� �H1[e �B浚�V��z�@=j�� k���n���B���p���t��QF�vc��K?%He-�ǫ����Z�����[Ӈ�٢��t��MW�+e+ ��X}<)�)�L�0�Y��Eh��t���o��fn�f2��)� ��h�XL� ��v�Y�2?� ���� �k��E���>ǿ��cF� �Q�>�� e�N�ؠ�:b; Kt�����H���w�t�ӵ�Jbu`��Y��-3��扢�U������RF���^+3�4��\fP��(6J �� R��+3e2�i�Q�f� a9�H��F�d� ��hP ,P ��\�lah)��1>�EV<�H�D���_���`Ω�rI F8��k��r^�F����=x���3:����7Ax������,!�y{H����ħ7�W�̈;�^'�@�u2g��B���Ȳj��B_�^�����BM��2� J;�S�A�p������JF�N�}�2��τ?��Hp�;��6Чg�u�#>]�,�{����?8P�3� �i�N'�W�Hj9��ị"�...
��'�"�۠p{>�Z����ٿ��������O��_D��7< ?���/��'9�~���I�.e�UQдj��^�7�m����=�����#k�?d=� ��bV�ɏ$�wF��z�G9��ˑ�ϲ��LT����?C��x�gk?�9�d�z�\�<Ϟ�y����C�+�����X�[G���$�݃y� u����y7��ʈ1�$�{��#j�/}�N�yb����H�_Lя��Y��W>����j�������� ��\��}as�R�ٶ�؞���~o���v˞g��2Oy�jQ)*���&k�������Y�k���������*�j��Nh�����n��i��x���;���V��3.e���u����y����zH��B�iwڅ�똫q�j+0:�8�X[ٚp< �I �q�V���]��6(� �cNa4u��� Ց�R ��-[�Α���#H��P yǮ c�e(v��:�u Qޘ��w��� j��A�{�PQ�)c C��فT&yq�cn�P ��{�{���=� �������}������-����=��G5B#f�Y�]�*�7�c�,j�OL�9�1O� n Žb�X.V�ub��*v�=�M:/�K��N�[��4pM�nH`7�A�n�]�:�!� �*�ߐz����t�,�wI}`'�Z��ֈ�硹�tX*��U`��~Q�+��HuPOI:��U�Y�3�V�\� ւ����tJZ#�����M�Ni+X*�jJR��Rʗր�J��ZiX��PZ�|$INԻD��� �l�q�Z�&Չ7�Fq�OF�:nk��F� H�5�WJC��ě�8.�B5��R�x =v��{-k;�V7�W�*��br�D�лm�f\�u���F�����@�]���6�W���Ko���~��������'��_V�}me\���MێT�$��=��&Q�J9}mQF����a�g&������H��ȃ������i�(I��b}.ش�N���s&�^�I�m�a��[҈���/�mdΏ��l���}�2'���D�\�|T�S>��P>��� e��I�S�C� Ȟ�'�1�2Nf4e���nj;oeL8d���#����F��L}�~r�����z�� �r�k��������o������ȱO!�~�u�����U�z�U�z�U�:�p�>o�I��3m}���^x��~rm?����k�����Zur-?��_�Z�O�� ^4�Obr�Ok��{���5|�SG�=��Ȑ�Χ5}[j>��p>���|�r�Ae����F�w�Z�XEn��œ�l!^@��"v�=b��/�#�$H�䠿�|RD\.͂'[���R.�R)OZ%��6 �m��BD��-�I%ȓ��Mk��d��ٹ��Ed`�� �<. K�wNKw��&���4���sǿ�)ޑ#�+;�����T^�7#@�ֲ-g�Ŗ��G�I�6c3�+��,_`��6NO��2i8���p����박�]�&�/�<�B�R��#̗�M��V�{z�|5[��Z��]l�r�v������7Ȧ�a{�2Q�F�U)}-~Mo�w��_J� �� ����2�QG�3�y>[~��-��ӷ��>�}+���w 1_���U|�Vrڍm��^� iԾHYC����2��G�|}6v1W�W�Ի�_�z����M�1}������ҿ���/@p�j�/%�N���V�l����q�������CB�P��wB��&�w�焋�%�пֹ*�,�Xr��Jj��U�y��n��Ժ�%�Jy^�LN+a|1��lw�u�].CQ0�V�,}��}�C��ylO��2&��M����>�)a�#�{x�S!C��c�1l�����i��P�g�>+�Ӷ��f��J�+�Y��i� ���NN�}�-au��s����F��O��T��>�g< ��o�Lx����a��~֢��^�rS=~��5c_�#��c��W��ׅ�(�F�"� ��DI��.���B�X)�*�@|M�!�!o��Ũ��k��N�ɗ䟋�r����G�6�m�e�O�TJ�6�>��w�z��q�Ү�L��������^�،���X7#>�i�>���bɞ�\z���3�J�;��L9�C��?O�>��Z����?δ�'2�3ҥg2� ]:�adx��_e�K���j���*I?V�jP��V3�N5[͖~��_}�ԣ?�?)�&l�F�1A2х�8��L_�<��S�sSX�*� ,� ��C]����> �&��2�Ovb�n`_ �;���'��P�*���l�j�i� ���:���{��̋�%.'�WS�k� `�oޘ�`��C2G�;w�I�F�Ӹm��ѹ��H^��(�F�Qd�1��F�Qa7��:��h6Z�6����e��۸n�4�[�mc�=m�l�4��m�c��N3�2(of��s�9|�f.��o���Z��(�%��5�z3��bn3w��.��5���b���U�[�/1�{}�| }�='S|q�Է�h�����m�m��s(��|��F�"�p�j�����J� ��-�{� ��̫�F!_������[$���h��Z|m����sk/�:�V_���i�w��o�3�w�w��,���[�e��2s��LO����;�ȟ�g��������Z���!�J��z(I+)�w)�̧���X��mhI)�h t���7�|�4�U��f��Q�_���?�?�)ڽ�n�_f��Q�Q��_��g�o��$9��d������a��J��= @���Yetx�<�cG�0 �@�<��) �s ̮@n`)il �� �m�U��G��u��� �M���큝֬�n�3�� ���ʡ�K��|����s*�`� 4��8��2W�K�?cv�w�Z���1��m�83���&w�#�!����so��a�EO~`��B�m�H��{�i�A�+гH?�iވ��s9�!75z���� j����gc���9�Pp^p�q<�8� �T��^3ڃ+�Ppup�� �1�Fp�Q�̞�<�, ����,�+�ǃդT��`c�� �`,v��m��|���*�:l^V����4��ț�������fVp0x�lŻ�FF�lCT�... �>R����UMD�В���|�3�(���9]]�Ώ�����DO����Pt=���/��{QCm4�j��V�ːe���xy��F������6����|�A,�Ȣ���,+Oߑ\�E���R��==�bu-C$�FW��%�1z4Z�^��J8�|?�Y�#�4Z�7�'����ѳ� ����`u�#zſ�(�vE{`���F{t�4:b.�:�yNFǂm1�rDL�9̣1#����r����.c�sf,�L�?6�V�le�"����@���\� ��7��[�^g�� �w�e����%��q�3���ܛG{��*Z�{��c��X��E���/,�����m��� ���m�������w����4n��~!��8Q~Nl�93��T8G�8MnI�TK2#ɷH*$�3g��ߋv�פKt/��e��l� �sɓ���`f$3�<��4Y��3�2We��ܐ�)Z��:�_ 2���ۍf�s�2wf��ܗ����g�,�,Ϭ�<�Y�����W���=�!�)�trD��R_0�{�۞y&�\ /�b楸���y5�Zfo�́�a�ސS�aķ~I�=�{�����Ⱦ���bS������G��-�Q�O ��Se a�H��W�7�����`Ku�0�)�������������~b5S}�y)}ץ{'F'������w=�UTW�ޙy3���Ә��F�!B�)F�b�)"�b�4"�H1" b�)"EjY�YJYJi�4���,R��F��H���ȿ�(E�,"&{��μ�����R�����9��s�=��s�̼;3�_�x x�O��C~�oe�N����� �����5+�'� x"�x4S�?[��"��6�ic08��9 �!H��3�iO*df��,dV���9��g���.����NL�G�;!�}H���I�lA�2�!%�J> �s�8e����#`���S���*ȿ�z�> �G�:P)?�*n�����ԫ��:�)���"�_���U�A���?����"��H�P4�� �j�d����Q�Q��s%�B�A�W�26��������|��<�aE��+P�Fϻ�a˜3�� d�P�[��lx����w���b.�i��*D���]�ѳ�o�L5s �>d����*D�1�(e� ��4����a��8Z�h�< Nذ�ވ�Π�����6��䰤���:DN5���^=U�WZp��a���X��q]9��F-[ϩ>_�a ֕��贡����0G�'�z��W8Uێ�g&��\է�#��������d6K��! �]���lg�҃v�E���>�;`�6Ȝ����ƣ�3*��kU��Z�5����j��'gP���=�nͮ���|݂(k ���W��E-ރ��yO�����~�3����W��� ���ȩ�� ����Kh+C;n���#o��+K����l��?�:^�:n�?�G��[_B�V�ӄ��@�J�����hVc��w�ѦρS {Qz�{�Q��-���������#�Pk}�7�g��i0<� ���"�2 �t="�<Јr�@r���xh�r'�d��F?}��F�� =�(���.H=��J��#�{*����"��}��;��7|~ J?�I5J��?��@�B�5���Ujt�B_ȅd��ƭ��T6���nj�g��X�gx~�ҩ��<�y���d�c4� zF��sv#V� �KjvV�-�������@~2�FH~�z�A��p��A�5��`�T�v�ὣ�J�C*<Ёsɍ��A��4��:��i��]�v��'��dMG���/����s0��p�"�:��B��^���Q�`�A��H���O:#|3�5���H���s��Ih�Q3��" �y��o*�Q��C/��x♦J:��'(k:��G5#�_!y�2@���A���_���X�g�+Ԩ;�g�9��Z �� ��5��9�ҋ�|�L��;a�85�@f*�u�!��c��ݪݙcc|� g����i�9�L�5� ����1K�ck(��4F9�0��K�/������ ��WИ��.�F�_�h o��O=�x舚�C'�ܡ��I�9s%sR���Ts�^ЅXip��J�G��z�A����^g���-ә���Q�k ���(}�� �L��c�N�^ rR��B����C����H ���A�}�3H��Q���8J9�V���:�<�70ϞR�ɏՊ�_m%,?�V�WKA)�a�|�'X���4O5?�� �k�G���O#B��}D�����I�uN:�� �Q�4� �ꄊv�Ơ�j���?�툇�]����� � ��+0�����H��F5�� �r�� ��骰w�8�N���1FU�ow@�h_�#Ӌ���m���Z�sD98�W#shm�-�8j����*@W@�5�"6���?���6�� �Օ ���y̞�5 5� �+�"�S=�՜�||44�y ��12Ќ_ù0���l���pja�}����6��'.G��<�[�8G/�+>����f... �s�)��Q.:����#h£��3Zw=Z�v�0�'�'En�[�Nq-�L�Z�ߧn��Є!��k)�ߑ�-t����/�U\%4� �O���?���&n�ёb�����W���W�j���.�Q�9�_��(G��%������t� ���G���+�xO���Q(>��R���ǯ47I�V+EҖ^�5�~q� ʠ �2,ʨ��A� y��E~F~F �W�+ŭ��b�������� ;�������6y��J˫���v��Q"��.b��F^#Jie=S���hQ&����N�@.�y�-�"Q.����֮r�\"�K�R1�V����L.#�r�\���nQ)Wʕ�r�\%F��[�'��5b�����������#��ϋ�� �Q%_�/��K�%1V�N�N<(_�/�q����b�|E�"&�W��!��|ML��������b��-w�G����{�^�|S�)&˷�[���<(j�ayX|'xs�f1%���W<�>;v�|�w���_����h`�L��%�~qi$��F����� :�%� Qw��Ab�E���ڎ�H�>�!nNZ��2�Z�Zf`R{[� JjqGG��$6k�_iR����D�[�(3$�͉2_Ob�F�j%34����A&�nK��,H�{�� U�ZW�I�nO�ړT�$AjoR�a �OD 3��c}iR��9ڤ��$ַ�*Kb}[�;�X�Vjx�u�\ٯZ�$����Ҧ�ʓX�V�I�o+U����Rw'�����^����]B�Hm��Im�F&���r�&��tGR��U&m��r�L��m�F%m��r�%m����t�F'mٶr�Jڶm��$mݶr�'��p��$UT%�/��I�K&76�}��lc���K���>R�'c��ϵ_j��Vi��5��������_�������E� [����K�� K�O�$��w��s��~3Vk���Fc��������Wv{��S���ˇ��>����A��q�8��9��cx|��'͓�����t��{z{ ������n;y�=e� O������L��x�y�����m�/�]�^v �>` �f"h�����30v٫}��'�72n��z�?Z� �E�b��ک*v� �_@��w�����#�� 4`��|���W���@>�� p��Y`/m3�P��%8�m� �(K> |RW"��~���7_P~��lZu��{���/��[��%b ���x {�ŷ��{�_.���P�����C�h�� �h�>tm$R�Y������>h������`�5]#1��m��/^^REw`<� �,$�\.��AO0�7��~��w�_G�T�,�<�z"OT�p��|<{!w? >vj먻�2#��Ј"���=�A^M=E�'$�J��^� ���� ��܀v?�|~�vcf�AGs��j�����3��#�� ��1���U��c���g�g�qk��5�����)I>~2���s���|��$=�#΅\^=�����_�ot�<�H�x#�>Z���QN�$��:��Y�eb���b��n�Әك�ٗRd�� ,Kz)�@���d�;�9���烡��Vr�{[�u_܂�тmb*��W��l:���d�E}�qۍW������ӕ�y8*�;L��$�o�^��Q�����i�w7|��3���(!~�g�-㟼�LaҬ�G)A�e(�rDΎ�9;.k��̑�������=rv$��?��W��������������c:}�Oc���z�-��=�!����� �Ds����B�g���l?�g������.o���#���Q�oy�N�>��=U�xj�Ǩ���b��8���`3�GzЊ$ͱ�bk��S�>F�V�i�8���Y�O���'��-ܗ����k�G�~=⣕��u�'���9T�Nm����������ᣖ�Ά#b���ۂK�rǧ��_���凷�}Y����y�fsb+���v��5�?��<�������g�1qW������gU[����>���s�""V,�""`����X�"bEd|����R+CD��C@Ɛח1�� s2TDǐ!2���Q�"""bE��=�'�'��|��������M�INrOrONN.MHZoN�r�.���F����e�͛4����K=��X�yݽ�:0q-q,��鬒�^+��Z�g��~X2X��lHc�!�xf�,���S89rP�N�}�07� NL/�T�:��P} N\/T�G�ӌ���f�][�El���OSi=b��C%�Meޓ4�A���������M�7�3d���Yʆ03~�s�o_��1��>'���f��G�gO���3�Y�\r����%�2{����:{������a�&��> �t�'k��ko���̒��e�6��̵��.���M���M��@��In�/'%<7MΔ��ͣ�B��ʥ�Sl�\#��Mr+=�]�2�P�{L��d�Y&:�q��t�NmY��vҝL���D�q���q��IN���G��S۞���|y��:�B���ᔐ�u&8����ng��3G�q���"J��,v^r^sVɑ�*g����,�ٳ�lr�mr��\��"��0Kw��.N���Ɂ�l��G��YTe,�]bb���v 4 ���9M���ut�:+\]��^ �@�Y`��70$0 �������!�сq���q�����������|r�����D|��DT��U��q���������������}`G`w`�.s2]���A�sk�ueo7�m(k� ��c �7�m&��٠(� �6n��"\W� ��n{��͕��+�.n� O�����A�7��4��@���Y�HnuJPC8�pʉq�R �c@�~w�;��4E��Lj��:mݙ 4�v� ɕ�Ke7'�.wW��e]w��^Ŝrwy�v�B,N��#Ժ"�z4v �֍։�n��C���Zɀ�0�`T��fa}���-j�d�-q�h+�FoJk�h�h��0Ƃ����uZ`��O�Y���֓�#� �j��w�nC��( �E�]�Z�(ƾ��vC�jca�Bc��@,��c�@����% �K+.B t���V��_F�Zc�h 1c�T�~%�dc�2P�5ƿЦ�5&��� }nm�S��d� ��|�j+��1�\?Az@m�y�-�!H�|�=W�~X�& M�� �ߨjХ�Y xV�giѿZvL�E'ӳ*��Ў�+�2�3#�6Ʋ -A��m�ڣa!X`��+��~�@...
���Ӵ�ME���>�>Dm� KC�7C�_\������臖G��>� �$M8%0R� ��ǝ����s��W�S������6z�>����1�8Sw,X�V�Q2��+��>�Y)�:~����3�Ly�,�u�V]XQ�)�����⥾� �1�N�bSO!��[����i�nܡfU�H�%GU�� Y�b̀�N�t��V�:�Nmx�a�N+�n9�2ب�6>�+��_2"4Z?J m|!N�)�w��4� �>ޏ�F_���L�Z�#�R�����VS}�1�W6S�h���(�֏�Vɲ�����+�/�v��ݏ�Zɚ�/�p��Թh�32�GL����䪬�45��%U��T���<�Ś���W�8�1�dG�B����Fq��S:��Q��#as�� '��Ep��64/�0e�x�ֿ<p1�����w��~K����L���uq�i���%!�5����[�Xf���b��% ���_S���F���=\t*Ra�� (v:R!�=ږ���w�K)mY��j�F���ݚ� ���Y]��Qs�4>�z������D���Rbq�^;�/(�{�D�tc�yo�D�Yfc~��}�_�8랰Z?�01� �c���8I�a�� ���p��|ꌻ�Η�ʸ���Ҹ�n �:㮺m|*��궲�_S�q�c/��\�[�ԛ1�{�w�_�������>�i[]SO�9��6��ݚ���T�G��yt7]s+?�x��gZ�D���6�z�z���:!J;:!կ;��1�� ͎��QF�^?��x�jY(����@�I�F�<�5iӨ��xv24jҪ�/�����[�I�6����iT�x�>?Y_�k�ʱ�LM���s�����d~ϯ.��$]�I��4v���[�N*����Z�Nm�ˋ�k��U�UWݥ[�[sg#>�ZHi��Rk9� ���JYom��Zۭ����:h-圻<�k�t���&�9��myމ���a��S�����*Í��y!�Kx�p^ �0>a\*���r��)�%���Z�G�|�L��[e�>�?����%�U|m.T3g��ic}�gU�>=�ϼnC N듎��>�k���<��{�^~��-N- �Y4�rq���<�>k[���V9��o����-ǙN�����qFV�``N����>s����>C�Oߪ�Q�e�~��s�8 ml��{��c}gF�Ih}Vx��'e�Ym��G!�3�����=����;q"S��8����aK#�S����|����ɡ�0���S�T�T���|�|?#h��W|�u$��ʶ]�-U~��Ω�*+Q�������l\W�j&v��ein���L�́;�qZ��Ȣټ#�I=���f�#ߗ�ʔ��8V���.5�/E� ��'�il��g����_J�R��c|���i���g���J����gڥw\T�B�������1�2-:�x��h�@;�3������g���yEzttS+�{�r�"R��$q����PX�Ɠa^�njiu���2�NXT��"6��$YS��$j��h�" ϣ�©�썕.��[�3��1aF*�=�Ch�r��C�����8�1^�y�ΈB��g���72���v �5c�7��2���h��ӷEq�zUޙq������JҼ�}Xڅo�Rj �N/���QX?���7D���N��݅��ў�\Z� �,�lyhsL�we����G�6�����4��sNJ��"� ?���"y��'�u=�c�d5�L|z���{R�~z�1==���~ꘞ�u���M���U����j��>��GQ�ģ�\?��czzR �Ί���*9:�3�� ��D��d�x]������������S���N�3�Ym�㌯dé&<����Y��"_-�P�43 �Y��bjf���@� ���8���P"w�*)�b�R@�v�c9�ʔ�y��wM���-3�����*�1v���= ���on�}־'��� s��D֔�6��&��'�.��Z���?�*P3DS�� ����0�u�... V2��g�G�@���rz��mNr����*%RF%=�N5u']�FzN`WA�GK=��?��`}�t��f赦ލ���h�q�߂���Γ�s2��#P�Lj_#]�Ki�,�?ma�wL?a b�ۘ��kNn�Ez���E��y%; j�����>��I����k=�&�Xd�EwfF����g�b��f�ziL�-�i�M1}61f<'��[��ў�3.���;!@��5��;?�{���,�s� v����5�M���P#��p������5q��� �a9��#u qFXf��?�By7QJ�K5e����R�#5P�ejM?}��6�@ �!-� i���ak=Fs����D�7�F�'e��Cd��7(0�Y� ޅz�P�D�6xH�@|Ŷ�{)����t����%����`43�Vd��ZW�gF�t�������N`]Zbӻ�cL]���|V]��������;|6�D����^���QErw��ۊ�����w9\͟�ٴ�zCZ������2�3h_ʹ�hZ�V�5�kM�&[ӭg�9ֳ�q�e��1����2 �o�=�����>\��/���ǒ����M:z��̔z$��W�MD�(!@|��C��A�\�Vyŀ_�^�i�>�-f�b_Nh��-E�d`����}Q�n� 4���Vm5ޑ?��w���dkI��d��>}Yf��� غ{�� ��o��QЧ��j��1��5]i]pS�;2Y�[�t�dŷu%8��� ��$K�y�>���3-ص�v�S��s��3i\g�Ki�^E��|v������y�b�C.�u�u��K��_����X�.c��j��'�~�o ���|v �U�������z�!ЂU9�~���a��&֕f�{�O�0�0�~�嫵;�]��d7�.�V֏ dE�A6�=��F� "��A[n&k٭��Z]gi�N�h��nf�X6� e����h�8�(��Z�\v!kͮa7����f�Y1{��d�)�*��,���6��n!a��=�J�#l {����|h?�0�+`O����!��G�ׯ�}C�D��s�\�p��� �ۿ`�=v�,�怭�v�_x�}v`w���}T��.,,8v@Q�~��i���,T8��^�p5�:�����_`o�p�n�}�Z�������yA���v�;v�/��_���p0��a�#� 9p�D���3��"9 p.�|���ܯjY�p-�F��C�p�^����E� �00X�^��4l ��%`+�vC�+�������z_�!N�B�ဣ' ��2g�L�ـ��.\�p ���z�M�[��$���XxP�t���@�``#����l�0P�8 �k��Kj��YU@�~���k�O%ա��2��Z�y9�uWЬu%�&�i���ūi~��f�ki��.���B�f�:���Η����^PМ��ΩA�¼|d�R�4�֢��6�?ژ�.�bw�i]}S"v|M���Z%<� ���6��o� ��U��BUB�T��*��7�E,�!s��aU��sSU��U@N@�j�U�q'[�V�����'i��՟d�1$)/�VY���~��1��<�o�{D�HY���$z���D�3ijb�X-6��”l��Yv+����l����%r���0'�d:͜vN����r&9��E���Ł��Tw�[��8)')7)��3Ó�%MO���$iUҦ�I����ɍ�s�s���������𬊓Ԓ��g�����F����5�x��4���ג���Z��Z͌���3��J�gp㷍)��:�eG�% �G�ӬX˔0����g���ƗY�VB�n|�����w���u��S{�+�o�s����������{�uє���$�v!y�It�83DTd��~�t�2��g61�6�g�W���~_�������S���g�?y�O� &�s��b�*����W%ķ|O|O|�Q������E�}����xV��x�������x�i�6!�q�ބu��j妛�i=����%� �V���H��ᴺ�&��l���̶��u4�m��m�p�渐U��4�t6����`�_f��e3��O�ͧ���[�k1I�-�75�3�/���=�?��K���o��ڿ"���o��1������m��A������pw�E��&7���tH��%ċ���ĩ��]��o;3!>?>~���x����敛w�ϕ7�!^��e$�W'�i�6�-d��2���e�V�1ۭ��y���2��P���3�iŮ����o5o�[��֥��fZ�[�� �t{I���y���7�u�1�y�t?���... ���"��H.!�����H.#��� �+H� ���*��H�!���i���PD�Z��_��L�먅�Ndd��xv͔��Z��t��L�먅�Ho$���A�I$.H\�� �ɏH~D���+��H�"鋤�~H�!qC�� �;w$�H�#鏤?$H<�x"�D�� �/$�H��x#�A���/_$�H���!�C2�$� D2�@$�H���# @�$I �@$�H��! B2� $��# F�$I�$�HB��"�Ң�҂Z��"��! C��G����͇�qFP ��i��iQ ��i��iQ ��i��iQ ��i��iQ ��i��iQ �[�lA��V$[�lE� �6$ې�Sl�'{�������� l��T��X�-g��,���G�d.���fq�x-(�[�����n��Lw!�@Tpޞ���3�� �+� `������'����8h8λ�z�����q�Ϟ���ob��2���_g�g�7I��M�4�MA;��`��Ǩ��8�a<�y"F�x��D���ω��1��c������,#X<��D�]���1F�c\��X��'}|"F�x�6�a�1��C���`��O{��JW"G�I�rx��׳%p�d؊��-�$l-��B�[Whؽc;n�G)�wYؓ���~�3����|:�&�<�fx/��6�|�"�W>^����I���x��^w����5�)�#��g�9�,�C��^N�Y�l��V�{������s1����XrI�U9k�w�]��������Ն�(�ˣ�|��Y*!���߷,�mV��k�V))��t@����Z�������{q]�]*�w*Q#\Je ���S��#Y��a��}���=�G���N�?K��RU�[�+�E����t����S�?.�� }/+g����٣��R�_� x�����\�i �bo�)�.����,]���t �?mb Z��g��K��-g�k8ݽВ-�ź{_x�h"^��k�����y�c]O} :�� �����S.~J[�ژ��6�S���9\W�k�u�A��~�sк��;/`c�9�S������ˠ�����C�V������W ��g{�RvP�����i����=|���~?�������g^)�g�g���>i~.�l��X)���d?3Ky?3?����y���S�����ӷ�zq��%b?�u݈G���6�Dq:� ;@��]+�^�0a��+�v��a�� �px�`Z{�+O����QrW����L�Y]��4dss��i������ c�~��oo��X�3���8��} u�p�g�B��>��c��3N��R�E����^ ? 5ᣩ�oS�٧p�_H!�1����0Pˮ�����:gH��^�C����ͥ�!z���#�(=F��� Kr�pvm6:��F�������F���u?��\ԃ��P��A=�z 5����ț�� �9� ԗ��P_3� gJPyTT-j��(�_���Q���DCsN� �p��7���+X���Z8� ���7�%�p�[�~����~���Yf#��6�3�� �{���������(��ma%�����џ|���l�-_��w�%�'[�Ű W�������u�|_���/�)�G��i��yV�3��.�e��.�<�R��oo/ �( �2 6 ��AZ@�ӓ�,>� �ݑ�ؘ:�V����6]�-��M7��^4kG]Ae[6�g���8���#��3>{�����|��|�܂�h9��k����G�C�:�5uSX�q�+�Rk �b3n8�<��gc0>y�����3x~�����EM` �*�T`� 0U��LU��SU��*�T`� �{K��' YA֑-$��C$��&qޫ��T%_�/Ǜ���|m^�ٯ����������^�@>��G�c� ���g��^�g�W����~������e��Ŀ����P^�$X5+�Vh"�� ������"� >B�* �9����B��$� ��a�s�+NBy�*�O�W�(�F��h&Z��Dk����x�=D?1H�A'ƈ��J+���I��Q��NE�V"���ơ�@�S �D�d��TԹ��P磦�.@]��u1��tԥ���P3Q���@]�� u5�Ե��Pףn@݈� u3�ԝ�Y��Pw��A�F��z5� �!�èy�GP��C�G-@=�z�$�)�ӨgPϢ�C=�z�"�%�˨WP��^c*b~)�a��+Q_{��AuA��D=��� սD��@�D�B�F�A�� > 5�?������b�5a��~(�L17���Z�M-�sS�u+�w< 5���C��z��}�����6%q vs���؟��'|)z�>�/~&���g�10�[��$D��%�[����h;4x��E�`�V��BZ�z�,�����{���n�Q�ێ�l�Ñ3��|�i>E��e�X"*>9�<�H���Q*�P����d7�A%Idc��Ɏr7٪1K�a��$�...
v���f �5�mzh%�ܠY���U� )��7�@�^l���N+���V�5Noncͭ�`J�G3z�3\;�� U;���t��<@�$փ�^w��.,�X^Y�RS�u� ���xy�����������2���ܴ����,�&��_i�A�X�t��q�4 ��Gϻ5r��H{e$_�j᩸�e4���߄��� V~îA�}|hYΖ�F��2ԝȗFڗ�Ÿ��b�S�/�� �:�y�j=��q��Fh6D�9�|V������H>#��G�����!?���s�X�Θ�<��:�E���<&E�+¹v���9��i�qgc���}���jc�v�5�>v)8[��������e��3��g �q3Exj ?4�&���"Db��ń�(h��*�`�U ZHs}�E��ϝ.(�`ݻXK���MN�kH�"���'�?"=����t�H�ou�n��ݵuS��-q���$�n���u˖ ��(��-�n��iS�k�&�k�&��61Nh�&�#ϾϵϿO�?�h�c�`�����?6�(8θ�ψM?0�)�)�}���?^t|�q1���w��;��v�t��;�vքB o˟}��:������,� i���VSo�A�7�ܮ7���HO#mد��O1�)������s<�~@X�.�ղ��Z�p�]��Z��z�ת�N�u+��Vb�9m{(�зI���c�{bp��=F\є躶i���5�؈T�T���$:�W|\O�A�{�$�㊉���e����Þ�-*=�����ػ��RR�l�Iɶ��[tL���pZ��(��l�*�.����ao� A�Y�b�(ة���z,�ɏb0m*O�>��1���e�gt��F]e�.%h�P ��t��P�W 5.��+ ��.�he�J����؞���^P��m,�?^�;E(A)���oSΗ*+}i��������P/ܘVI>�y��͛��'�5�S�7����]���1xS�JB_��W�by��1PĠ�k់������6�+����.��+|�Ē�H>H���ud yy�}��ᎲZ���]p�{0F��$��¯�M@}� l5kf��ij��� �e%�:��Уz�{�s�$��2'4�Y���X ����sJ�y���X?�^йE둞Ɲ�SܰUE��#>Dw�O�X֍��t������J{��e��!���2#��}ha7����/� a�Q�Y)� l�ͦ�{�)��8X���*} �(�m�#b����x��eA�^��� ��cn�rP�K���A�۟?��`�?��2,7�j_�_���K]�^����9Ўa�ڦNR+�vu1��5���W���:{��[K�zY*�@�sO��mQ}���H*���N��C� �.D�p��:��[:B��+j��:�ר}IwB ��k��bw+�D<�_;��}�=N�3���f������� ��3��(��e:,�%#O�y��U��?m����9��>�L� � �{�{{���,v�|��_����X�@��/IV%V3/�U Td�]�D� 28 s... C-��� �Ӆ�.1l��.�tag�t� х�.�K�Nv�;��?dV��*���L��Lf�0Ӆ�.�ta� 3]���Lf�0Ӆ�.�ta� 3]����5��f��L���_3�k�Ӝ�Ǣ,kb�&}��}8��A���5���c{l�yM0� �5��&}��1�5�[M�(�̀��6q"Gk�hqf��a ?o������s�v���Q�9j;Gm���]M�$9r�#�9r�1Ō�bFL1#���F��l�9�vά�3k����Z#��ٵ�Y���v�0N���R䱢���3G��+�J�g�c���n伷q��8�m�(1H G��1�Xp8�y�v8���W����+�8p5��c�@1� ��1��[���6p;���`&����s�\p��;A ����#0u%c^%��6<��xlS�y^��J�_(��i�2��L��������E ��ΖY(^2Ԓ� �gk��A�#��k+�s�X?�`�$X?�73����A%�s�8 � �P��A�#�گ��u ��#�y�:A��:A��:A��:A��:A���N��N��N��N�9�x0����L� ï0� ��o � ľ��7�b_C�k�} �O���`��F�_Ŀ��'����� ^�W�^�gr�C�gV���8O�*�_��ԖyDoQ�S=@.� c4ߡ�����p$� �����vDw8���~<���M`"�&�)��?�w��x� ��`1�,�� �y6?ꏘǏ�?E�f��W���<��ę��� ��ߕI���U7��xHI�! <$��$���CxHI����0��Lb_��}g"A�0A䰎֑�:rXG��֊Sk��������-~^��k�WG>��?�u���?���Г������M�F? U�������;d5A�h�]t��ά.D7���X#�5�X#�5�X#�5�X#�5�X#�5�X+k��D3�h��t��N4Ӊf:�L'��D/���t��N�҉^:�K'z�ܧ^&q>��p�e��n�����>����/g��t��Il"w��p���|b8��88��f�9`n�]t�c<�ĿN�5�g��~R�c��d:�T#�j$R�D��H5�F"�H��T#�j�Ɋ�|�n�/K�L����I1o���L�(W1��f�� ��`!X~ ^d{�� ��� �;H��so�<��7�� �dۯ2���M�I? ����V��*���c�>So�#A�L��,mN'��)�6�g��Ù��消���ߟ���(f�bf�b2ZL���P1*�i����q�bf�b�TL䊉Z}�]Ɓ�|�qQ�'j?����,&Z�D��h��z�U���2���2Ndߓ�d0��kS�-�Vp�L�,!R���'��H-&R����]��8�h-&B���1.&:���<1�(xD� �6�/���=j��o�eZ�z.�+q�=}�Yx���w��`�ϭT�̡ *�8_��Dž�q�bF[��Ѓ-|��V�o��>R�h�m9�-g�匶�і3�rF[�h��F�F�{���&�)`��Ƿ�:m�����і3�F[�h;m���ӣ�S��M���Lk蟅�?��2�m�mg� ��6�h�m�5EB�О�ϧ��vN���}��)� �φ�)�"ax��ljHc��ȼ�S�<�S�<�S������VX� �φ�)X���)X���)X���)X����v7��Di#,O��,O��,O��,O��,O���l$��D��h6�����D�}��>,O��Q�H���V�O��S����G�!zk���{���Ǿ�j�������w ���<�� ��a�_M�9��6�q6k����K�y6�<����y3� ��8����$����xp/ 3�03 3�03 3�03 3�03 3�03 3W����.N���.N���.N���.N���.{��.N���.N���.N���.N������n_'ap�ap'Ʌ�Y�Nn\��{��f�B ��8�� �0,��Jr�w���G�V��������1w�g~���v��X�<�8�%�c�+7_�C�ĎuH��ڿ+:G��`��&���&~��{=��{��Zb��_��W���������H�]F:0��`� ��4��Hi#m`� ����60�F��Hi#�a�5�9�ķ�t�Q60ʆ]F���!e���h�_[:���F9�Q�`�#Ќ�8u{�8�H�^G�cu������uͮ�ʎ&[�H�s��W�I�,ə%9�$g��̒�Y�3Krf�+'9�$g��̒�Y�3KrfI�,��}� 怹:��� �0�< ⬓�u2X� ��8�$q��>$w���H*��T�ۿv�։�>3�*�x~�� ���v�3��l���(̌��(̌��(̌��(̌��(̌��(̌�!�o(8�.�Bp� �9�u���c��o���m%[a`F��Vu����A�eFwՏx-{�#����c ��C�Cy�m#�m� �� C��չ�c�����W0� F^��+y#�`���_����68���@h�mp� ���7�F߮3������p�ŠD߱�пQ���+t��iE�7�x�����Y|W�w�n �LG�t$X�]Ie^��H�2��"F��/bċ�"F��/bċ�}��p��mns7�] ���(��j�g��[���?�y��,I}�2p���"��\θ�3n刭��#�r�V���[9b+Gl�H����4 o��jr�>���~k���t���w]1������\.�a �ڨ'��d��������:������z�^�K-Q߷�Zb\^��l�s�_O���Jy��O��)g�T��z&/��U=�n�����*⺞���LR�$~CD�uD*�u;��k�T���$�D��HT�J"QI$*�D%��$�䦝ܴ��vr�Nn��M;�i'7�{��*a�^?����䭝��3��K1�J��N�R����O1��G}E���m������]�%�yb���qu�����Mߛ�k�U�����~5�����6����^\I����5����^... z���w��/8 ��Bp+8 � \���ɠ8��������5���-�6p)Lp�\ �� �hp �ׯ�ԉ�L�v���Hp ��ׁ���`�nw��B����A�T0P˨�|p..C��`8F��>�о���5��ͩ`:� �~`� ����7 CMVSx�.�|��ˢ�����q����z�\]���z|��LJ�z�<]����� t=^���t=~��LJ�z|���G�z�{����Kt=~���G�z����L���z|��ǯ���X]��J�HW�W�J|����+�t%~��įѕ����NW���J�]�ߨ+����+�b]�ߤ+���+�ɺ��+�u%>UW��J�V]�ߦ+��u%>MW��u%>CW�3u%>KW�u%>GW�su%~�����J|����ԕ�]�7u%�@W�w�J|����J|q��s�࿊����'���Jj�l=�O{���������澺:�-��N�����JerD��1rB9j�m�d��r���-砜�s���]�9E�C��P}� }��_ 5����W�1�������B��ǡf�S�OBi��"qB��g %C�PK�5�i�жПC mu�ҡ/B }j��6mz�v����}������K��j����N=������CD;?��1�����lc�,�0��?�uDC� �J��!�HG@B$""""�G"ug�8�d̹�Z_j�|�[_�X/����|��7T"� �2�L��[Z�Xc�����s��眛�������lG&���J"�>�c�ӏ ݵ����O���p���S��İt�+c��ve� �#�/����7r9S�� _�K �s|�!�!� ��1|���8��#~�I7���ٵ[��9���w�������u� �0�T�x�(~|�a��8����' �csv�Nz�>���l�&1$����I:a��/��(���k��>�G?>���� ��S�St@�݆t�aDGHq��/�~�����n?���2%��z�K�<Ǻ;8�>�I��-2��e{�ή�e�2o�w�n�yϼo>0^|%k@6�_�Y�9g�C(b�{�?b@,�0�I� ��D\�$\�+p9���\�,L� �a� 1�P�%X��Q�Z<�V<��5��|���:�DꐋF\�td"�+13��,�mX�2T�.ԣ�jތ0Vb-�c>� ��&\�q3fc� ��(�,D)�1�P��q/��Ch�r��j<����;���4�����5...
�eZFJTh)Q���D�V��ZMJ�h )Q���D�֑�ZOJ4h)Ѩ��D�6���LJ�h )�"%Z���h�6R"�aR�]�I��FH�� %:���X�ܱ�^s=)�()�A7�]�EJtk7)�Y7�[t )�U����KJl�m��v�.Q:��H��CJ���?�K�%H��bI���n���?�v������9l�/rף��ǭ�O�\�җ�U��������~��kB����҃�fq��yy.=�&��ỊA&�df�)̗)TU�)�� 9I�죚��U�T������gZ�y��Ϳ0����L�N���.�9�uji�B*�sl����tY�.��e��q� ��>��~��1N�N�c�.�9Ef��.X��9��3$[����0!)7���J������Xn�;�� +wC��'��}-���m����5� �vqdU8'm��H[NZi�eeNZySGx콿2 �� endstream endobj 282 0 obj <>stream hZ�o�6�W�K���oE�<�5@�M���i��@b��5���(R�ӑ�50$Q|�x�ݓ�F3Τ1 =-S��6��Yk���yo� @Q����VR�Z�@�Ăf� u�I-��łvXpLPgτ0�I�B(G`�H�/��P�$;J���@5�IE7HA2�� wL��ϔ��9So�S����)ǩIbAcg���X-�f:̃����o���R�����Kk�#8�rKq��'��H��iϩ���Y3�u6̀�&ˌPD�cF-�3c-��3�$v`BA0KLR�Y�� � �Q\�5a�a�I*X�� � ���i&���Z��CO����5f��j<ݩ=+*�mK�CpSM�x�{�]��H ^Ek�V��������7Ƹ�����l�1�� MG�/�b�PN��nB���dv��$� �\Fߦn/���vv�NT/��/ B�ژ�����Hj,��>�Y9��7��/G��ے��]9��#�����%��\v�)�>!QۅlY����7�c5߮G#w����z��z4�jCƢ���z��%b�b_c�-�k�R�VY/ ��qiZLZڈ� !߆��Af �,$�f\��)r�Eص����]�F��G�/�?,�f� վ\ϐ��oLQY/���m�yx�vK%�xv����c��dž15�m�~�����a�r��{ &͂�����O����g��... ��"�$�����-�z�(z��*��ثG��G���\'!!��\>��tKQ��Z�V�{�䶷 �-Ny�2>���g��M�L�]��g����'��Ml^<�]-o�����C�*ll�f9%c|�wh0@f'��b�(�O�⼊A0� � >7 �rP��2��cqHK��c2ģ�ɖkyۉ�ܘ������ÜW�M7�u&��`""�'��Gg'vo����_�$\r�\�%��Z�o�|!O��!�`=*XM�Ƈ r�����;"���VwW�q��?�|�km��K�~S�P�J�)Z�>h��U������P�����h�A��9�]?D�~�/���OV=�w�N?Q �F?f� ��!|� U�H��Ba7c �(�Uh�ǎ�V)7Th��3� "�#rr$��.� ���F�?��� �����8+��^� � cU�a;@(��B�4��y#F�� R�����c9;-?�����}O{�!���L?�Q�~U� :��'���]~[��UE�=�>!�{�[��vBI��R�Q��/87�a@i�6f�v`7|&���4'�*��7\�'��! ��8�w�} ���b���ǫ��*D�Ӂ���hTlW�?-�q�jZ���hz�2�d&�B c*k��gJ�ކ3�_����\��T���y�9� :�'�>z.d�>��\��{.�`Є������p�L�(R=���f�oD2���\� $�]���6��C�a[e�JA��(�Ϫ������L9"�E �X=-m�{iS����ڏ���fY��x�z��_ϫ���O��e&� endstream endobj 283 0 obj <>stream h�̛�n-�q�_�߀]��?��Fǂ! �q.h��tth� �}V�^k�� �� Fr!q����=5_WW�������^���6�����m����� 6��EKm�.z��6 F��|dB� �����m9�a;�AL\���g��[M}/�x� v�����_�Ӱ�w��4J���4���2Ď��fl��FCt[�i��1�bX���<�_ �s�Ű�o~�f6\�3�����4�`/i� "��'ط4�O_��|��C� ���4�O��r� X>A�4�Op��� X�}�cK{��� |����|�c�&��L{� "ʽ�q�v�ַiio>�Y |�w�>� ��'8ay�',O� ����ay� �=Y�>�=Cm>���<~���ث+���A ��ey����'���g��d�}7�H�� A�A̤e����4\��� ��2|X3�Dw5��a}�O��a� �10�f�cbF�)3|'P�Q� >Ju��z+����ܯ�Gi���t�k�Q|� �ߪ���]��07�ࣆ�Ն4m>�@^4<�������7�����b�4���/o��k�����˧�?<�9l������ן��K�zyy�� ������x{�qY�x�]�x�]�x�]m��j�������������=�a9BZ0 d �����[� d ��A��#xrBޘ��BH .�,A��5�r :�l���=r#BΠD�'��A���Y�!k�"��ق!{P#�n��A��7v�]�A���Y� !k0$� ق#!{�$����A��7�ĝ�A��L... ?CV�S��x ����������D��ʊCGV���`��a(�8��W����������?�� ��4�n�c�F�X��#��G7Ŏ�Pq!�����b���\�����9��ب���Pq��K5���F����1rhǂ��\�eЍొ�Ǫv����#vk�� �) qu�P8&�H��F&���R��z+�L�R��Q<��X�@H4 =�2(z�#r�z�#bs.-3�E��ѥi˴�К�F���!a�څ���@��fx`"��s� ���F���c�Y�̭�T�}��P�'��_�LAًH�(�;����)�i��~���!�����w���kTR�{]�p��z~���Ƕ?7�G�tj:���''Js��(�� ب�Q>�ZFq�ZE0���Vd���p~��F!����5/�]T�!(��*������62��%#d2U�ɤ;��"Λ�x�x���Lz\����&N�c� n���∽?�N+���bъ��D'��@��ѹЗ�7�����������U�� �W�s�g�k�~��M��s:��:_���:��m�\<�xd9_��~&�!�k� endstream endobj 290 0 obj <>stream hޤX��]7 ����e˶ dWt34ݕ�B覅R�E��G�C˛��y�̜���l�Ȗ�Vu)Rk+b-~W��P����nK��Vr�f`J/5��n9����1�'�2�Ee�h2{�.s[Lֶ Y�2ŷe�o�� ���6�LJ��I���6�G l��Ϯ1�0�ϴ�f3L5z�ScG>�LhK���6��m�T�m'��:�h-����,��j�fJ۬�m�h�p�}�"5V�媭�儏�b�>ƶ��l�� sw��j�]�V�q���D����#���Z�`1A��c��t]@���Zb�"��D(O����`�e�>�|��`p��>ֶ���x����Z��1=P��. �2����` ���m&]q85�7M��m�`��9P�j��5f����D�1� >ƶ���6���k��cm|x����YE�� ���En�X|j@3QG^��� O4�[���P�¥ λw��������" �T����`����ۯ���|��埯������ߤ���AQ��Y��qGh���%4���ː)��p�I�!ԏ@C' !@[�o$62�^��k�N3�㡤t�N&�X4���*l� �C:���ƍM?c�����I?z��,��( �u?�t�zݠ�2L��������73�F�YԈ�d-�~��tti�vZ��)�MT=�t��@�R5��x�iAĴV���=!m�A�x�!��=��� � � ����!�̴h��D�3��&�W�"��K,a����%�B3*�P�����.� �W�����Q��'\��4N������GM�B��=&�K9�nv��i��|G��>��w�%����(2� ��dt��@_w���F�>b|wU�lUyE�,�X�` (qYʳ �ӷ�� �� ����WۥV��}C�tC��E�tC�tC�tC����+ِ^l.?ߤr�z=�Q�ױ����ҙ��y&]/g�K�kF��Zt�[=#;ٝ �'HG�bg��z&�����Z�m��� ҿ 2~�m endstream endobj 291 0 obj <>stream hޜX��7 ���W�HI@�[��<$�=A/ �!�!�r����Ş7���j(>�Ud��TѣX��R�R�b��Q�"���.Ƌ.����Q�b&����ɴZ�H�@˰��y$�2㱌D��X^��&Pr����cqX�.N��Jm� d@��� ���8o�5>���'��苃�X�J��t�vמ�[V �@YAcF...
�3�=s~�W�Ӟ�M�o�DN���W�������ٻ��wWg��)�)�)�)N)N)N)N�]���:}w��GЎ+m�Ҟ+m�Ѧm���b���n!��B��,v Y��� �$ endstream endobj 294 0 obj <>stream hޔX��\9 ��A[�l�r r2�-9$˰�,��=�ߧd%�Lgx[��.j�\j�����DGo�;�Uv仉�J�E�.V�+fJ/fI/&�}&�8nx��@e��d���ܚ�ey�CVd8#z���#�d���� (ڡi��\-VZܭ8d�!�^^zq����n��v@hq���cF�9�N��8xD}/���_�y��ؑ�YM�e��R���,Ӟ��E������Bl�ǚb�Z@��T�Ί%�6���c��2Rd�2Ҁ�Z)�0�����]��ːh7��p(jořt-��ҭ�TnR/W�y�2��������_�8x��ొ��*Q<������c� ���v8Uq͋4�ĭe�兛�⽝� �잩(�g�B'���~�G&L��c��1���*�8xDq���ో��..d4p�^����>�$��&�o �_�����ÿ_�n�߿����7_��~���lV��V(�0Z�i����_�}a� �tV�`��� +V����k�t������V��J\�+]r�knt͍�o��F���ۋ5k/I�]��z8;n��Ύ[gǭ����q��uv�:;n��N�[�ǭ����q���uz�:�G������d��J��|俺�ۇO��<�Ӧ����Lu>Ut��ӊA+&�X�"X8�).C�, �B+�=,��b��Z�-K;vt����S\��A?��~,_*&�X�"h�f��t'݉AwbН�s�s���������z��h�п+��Y����-O�C%�~��迩�uB�)�!�St�ǵ����~w�Z���J���=������'A endstream endobj 295 0 obj <>stream hޜWˎ$5����v��N[Z� �ˈ�8��Z�=�ή9��4��&&���v��:mK��ɚ�WE�&ZL+�Ŋҋ�ҋ �b�x1[�a��8���bLf1]��X#���)�@�^=�m٨�h%h�n��ZVdV����9��� {q!:���(�p�ݍ�G��Fq�X��c�]<�\�B��A ��-���t�P1+ �4�)<�ȁ�!�SlD�2�1�� ��a�����ొ��*�8x��s+9��B�Z~y-�H����e[v�Lk+�Hq&�=۷;�N�v�#g��>5{�#@�?�n�No�No�No��.��.��.��.�W?�dd�\ &���Z� \+5�+t������^��A��7��b�... ��ݱ��H�s��L$}7��^i뼕��⾉�(.��}�ڹ���&��@\J">F�O -p�������}�UP^�"fE��R����G�gQ>d<����ֽ�)M)IYEj���\�W���W���E�� �`_5-�hYM�� �U�ὦU�ƬՐ*ޘ5R�V;�o�eϥ�C{�VE���� ��3َG��7�3�3�1c�;��u�)��w�1O)���\=��E5-�h����Y endstream endobj 301 0 obj <>stream hޜXMk\9�+���RKrKX��Ʒ%� Y�ɿ�j��/3�q��LQ�T��қg3�j�1KoF�M�� ��l��4h��� k���-�7�`6��f�Ql��6��6f��\6��+,��� F[]x[��Da��Q��FDQ-j'���n��2b��M �u�{�h���ͽ<�jtN6�w�cD� K3��p��<|��sw3�1W�<�4vƹ�Zaq���riW�X�mŒ�bIr(#�w�!ɡ M�jr(ȒÇ%����cz�Ó��'���u9�yÊ� .+�����0o���y�ʏX�CV눕�":��Ǽ���M���Y��'��;�.m��r}:W�7%�{�z����i������>~���B�����5K�Uz��_�GO[�?�z���o����?<����f�\VHY��-+FY�e�,+VYq>��a�TpY!e��VV���ˊYV���C�TX9&V���cb�X9&V���cb�X9&V��MI}�T;��N��_v���{9�^���#���{9�^���#���{=�^���#���{=�7%��S}�T�=ՇO��s}�����������ymc<-�����g�z[RoKJ��W�� @� endstream endobj 302 0 obj <>stream hޜX��d7 ��A[�dٰ�-���ln!���@�C�>%{_� =��+�d�j�t�K�t�&������a�Ҽ^" � `��)~,S�X�Ķ8o���c�2fi�IZ��K���Yz�C�,QOYV�>e�Q`!Bv�4g!D�V�awݟ�؟���RD�jYJ1D��T$P�VL��7�Flۀ�ض�ql��c�F4�Ac4ֱAcj��e�Dh�[�4`,� {T�YA��� 4��#A�Q�$h��H�c{mhy���eB#��:�U�... ]�tI�.K��x�sRV��Y�dEʊ.+����b�>`��鶛�{� O�䫘�c���������N���^�땹�Ү���M�zW��֮�u�}z_����o���=������]2�*\V��h�"eE/C��CD��L�]1��}1�q1ƍWa^���Sx�n���m\�q��MW|�������k �ˮ�}����=^�Fo妷r��lz+7���RB�!�ʐGeȣ2�Q����bȊ)+����뮛n�龛n��Λn��������v��t���q���q��/)�ʔGeʣ2�Q��LyT�<*S�)���(� 0(z:* endstream endobj 304 0 obj <>stream hޜX�nT1 ����Ǝ��R� ���*. !T�=�d�v�u.�y�LƎ'�����ZX[-J� U����G����j�4�z�:�":����3"TlE��Z�J��"eLQ�2��Xq����9f 1���b��Bd��!��I�7[$���Q(��dh!�Y���)� HFA�f̠�g iP_1h��ư�0h8y hx�� U�샆a0���,�m f��:�D���#ӎG����Q<���(=2�x�>g�c�9 4z�t@c�P����`��2Z:�e��h3I�<�g��襱F�c���D4c(�Ɍ9��#+ ]1h؊A�V }Š�|���2��tFК� j�4 ��j@aI���UBC���a��|p,� �@�&�-D�M��"64tŠ�+ [1h؊A��4��Ac�4F4��Aã=ƌM=2|��ٳ`cF��(:clE9�o� �nd��qww������{����O��%vI������������?ߞ��x���ݢP��yJ�S$O�<�ěP�Zx[Z�������_� N����_g��T�*���ܛ��fH��i��=�i��T�|�)�v����|�)�z�����'�o`~e��5�Ʈ�����^K���o28�hi���fX���Y1�x��O|���"E[RDZ���ڎV���-��ڱFM[�d� endstream endobj 305 0 obj <>stream hޜX��\9 ��A[�dYr 6�!�۲�%䒅%L��-��ɣ�w���T��v?u�=�I���k}�h[tQ� �t��D.��?c�� �@@���R|#��1�y�.� C� &q�u�)� !��mI�ҲD�� �V�VE(]uTَ�uU�>D�Uon���sVy}"�QQ����/DYh\�Jc�Z�ҘШ*Ac掠�F �`�X�F y0�6(�m,P�... �`��l��+FU 98��g��|�+炾�_�\�s��D_��='}q���/��)����a�>��}HY����!e�C��C���,kY���2��}ֹO;�y�>�/W�m�{[�ޖ��%�m�{[�ޖ��%�m�{_�ޗ�]�I,��z�$v�yg�?�������1��c�]���?G�����e��9�d�� e��D��H��W'�S�AV�im� ���"�o"�d�m���b��Ś����2Z����P7� g�I�ߍ *Ǐ����$~"��Z6Ӟ����6ڋ���b~��$LP�}�Ţ���k+W>����w�N����8�>�s�o�c� endstream endobj 308 0 obj <>stream hޜX�j$G�����|��n � ,�F��c���#����h4�>h�S��Ȭ��!� ��B>�3q�@��EI��H��I���.K#[�N�,�;`�EU�J�X����#!�J�Oz�� �#1��4��H�X ��y�@�[l"%6�@n@u2Uq��J���F��p�X�8b��+bt,B�Q&B��l!��/ܗ>��/�OHM���6Tj%�nXlA �:Ǻ�^�:Ĩ<�!F �hX�$�oX��\����W,�3�~n*���wA#���UK�ʻ��F���'B�e�вuR]�4m��ڴ Z6��eC _6Ĩˆ�G�1�F�1Z�*�P�����`�4f c��l �lF�����5�*YL.�0����Ě�u#f� ��0'�1b�(�`����+bt /)�QLaĈ�B�YL��`�3�� ���ɥ�g Ϣ�Z�3Z���Y��Jx� 4k���U&B ������o���uT���ß��1�������_ϧ���Ǐ//����'�� I34Ͱ4�ӌ��j`h��������o/�����1c�b���\�n�{�2ҔQ�NS �\�#e�b��[?���W�Xy .�g����m��˵�],�"?��Kq9~S����[��� �}�-yے�-yے���m��}���䖮�������m)lKa[... � 1�Dp�f�f�f�f�(��J0�ϴ蝾�H�Y F�� �%J0=��� &��m0�`B��f�4:氵�S!�C�+��_�~��FGm���yg5��)Pm��ӵ��.?~�q";���l�#���;Ow����Ƈ�ܫ���]�������v�lt��I=H͏(s3�FOR�)}w��-��v�T���w����z���2� EUe�j)�g�vR�G��)J�?�>��T����>�_~���%Rϳ���T�>�u�@��H�9��դM���� endstream endobj 321 0 obj <>stream hޜ��n7 �_Eo�?Dr�C��طEE��6A���%9���w�J���я��8�1h��ka��[im�������A[�傝ܰ˄n�B�ţ077�t��TK��Z_E4na����S/�B,��C�a���FjV�q-��T6v�"G��K#t&��{a.�)֙F��Ʀ�9���� LC��48a��1�覡��n�NXJ��o�s��b]7K|] x��f ߇����[b��}H3����%|�%�$ڶL�5�4$�Ӑ�V/-��ƐXg �6LC���-`E�e�Y�ЪKq�� 5�Y�!�b�v�-1+�b[@��,�� �fuE��ip�HM�G�,M(Q#�D��i�����P��0ԈE�U����X-لնڼ7зoEr ��5 ���2�Hq�$Qc���w-����(^-�D��K���ݣ��`���h ����)ao.��c��� �5���4?=�h�~�="�VX�sL�Lcx����3d�(�FT���* H� ��0� �����s�Z�8�Y�M�����P ���ǻ���o�O�?�����ۿ>���u����>���ȱ�8�W̥��|���;;�ϱ�o�s���9�z���"��z;0^ 7�s �#t��S} = ��#��yݡ�h����t�i���|�`�uS����m�u���}�}��Q�D����p�}��@�k�N�.rpp��\��X���d�k:��ȍ��"'��E�O�e��`�K��}�}��Q�Gam�h�FE���n��n��njs|��1��KV��_�xL�_�8����ũ>��,�9���L���/�����}>���@���e�I_퓉�NsS}< ��:��!���m���⽍�}T�Ѿ��:{H� ���]��...
People Also Search
- International Clinical Council on Fibrodysplasia Ossificans Progressiva
- ICC Releases 3rd Edition of the FOP Treatment Guidelines
- PDF The Medical Management of Fibrodysplasia Ossificans Progessiva: Current ...
- Medical guidelines for fibrodysplasia ossificans progressiva
- Blog 2 — ICCFOP
- PDF The Medical Management of Fibrodysplasia Ossificans Progressiva ...
- The International Clinical Council on FOP - IFOPA - International ...
- For Patients | International Clinical Council (ICC) on Fibrodysplasia ...
The ICC Is An Autonomous And Independent Group Of 21
The ICC is an autonomous and independent group of 21 internationally recognized clinical experts (MDs & Dentists) in FOP from 14 nations and 5 continents. In June 2017, the International Clinical Council (ICC) on FOP was established to consolidate a global voice for the best practices for clinical care and clinical research for people who suffer from FOP. on best practices for the care of individu...
Fibrodysplasia Ossificans Progressiva (FOP) Is An Ultra-rare Genetic Condition Characterized
Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic condition characterized by congenital malformations of the great toes and progressive heterotopic ossification (HO) in specific anatomic patterns. Present management summarized here is focused on early diagnosis, assiduous avoidance of injury and iatrogenic harm, symptomatic amelioration of painful flare-ups, and optimization of ...
© The Author(s) 2025. Published By Oxford University Press On
© The Author(s) 2025. Published by Oxford University Press on behalf of the American Society for Bone and Mineral Research. F.S.K. is a clinical trial investigator for Ashibio, Incyte, Ipsen, and Regeneron and serves in an unpaid capacity on the Medical Registry Advisory Board of the International Fibrodysplasia Ossificans Progressiva Association, the International Clinical Council... M.A.M. is a ...
G.B. Has Research Grants And Conference Support From FOP France
G.B. has research grants and conference support from FOP France and Ipsen, is a clinical trial investigator for Incyte, Ipsen, and Regeneron, is a member of the Medical Registry Advisory Board of the IFOPA, of... A.H.B. is a clinical trial investigator for Incyte, Ipsen, and Regeneron. M.B. is a clinical trial investigator for Incyte, Ipsen, and Regeneron.
A.C. Is A Trustee Of The Radiant Hope Foundation. T-J.C.
A.C. is a trustee of The Radiant Hope Foundation. T-J.C. is a clinical trial investigator for Incyte and Ipsen. C.C.: None declared. C.L.D.C.